I guess it depends on your definition of significant.  One of the most encouraging numbers I've seen recently was that in West Virginia even when getting trounced, Obama received more votes than John McCain.  Turnout has been tremendous and the forces who wish to see our Presidential choices not decided on Race or Gender have overwhelmed the forces who do.

When race was pushed forward as an issue, Obama reacted forcefully and eloquently against it.  That speech played a huge role in securing him the nomination.  Among the many faults and misplays of Clinton's campaign, perhaps her decision not to address the role of Gender bias in our society should be added to the list.